Finding candidate molecules
Somewhere in a huge field of possible molecules sit a few that might become medicine. The cluster searches that field far faster than a lab bench can.
Health & Research
Our machines, put to work on medicine.
Calyraen gives computing to health research, then publishes what comes of it, free for anyone to read. This page is the index.
Our part
Why a computer company works on health.
Underneath, modern medicine is a computing problem as much as a chemistry one. We are a computer company, so we give the thing we actually have: machines, and the people who keep them running. Researchers bring the questions. Our machines bring the patience to grind through them.
What we bring, and what stays theirs.
Imagery in production
What we bring
A dedicated cluster, always on
A set of our own servers runs without stopping for research work. It is given, not rented. We add engineering time when a project needs it, and we cover the cost of publishing the results.
Imagery in production
What stays with the researchers
The science, the credit, the conclusions
We do not put our name on the findings. The questions, the method and the conclusions belong to the scientists who do the work. We are the workshop, not the author.
Where computing helps most.
Three kinds of problem where a large machine saves months of bench time.
How proteins fold and bind
We simulate the shapes proteins take and how they lock onto other molecules. Shape is what a drug acts on, so getting the shape right is most of the battle.
Study data too big for a spreadsheet
Some datasets are simply too large to open, let alone sort. The cluster sifts them until patterns that were buried in the noise come into view. Months of bench work turn into weeks of compute.
Protein folding, our lead example.
Proteins do their job by folding into a shape. Predict the shape and you can predict what the protein will do, which is where medicine begins. Our lead paper on it is written to be read by people who are not specialists.
Imagery in production
Read the full paper, free, no login.
“Science paid for in the open should be free to read in the open. We hold ourselves to that on every paper.”
Imagery in production
Open by default
Everything we find is published.
Every paper this work produces is free to read, in full, for good. No paywall, no waiting period. The same rule runs through all of our research.
Browse the publicationsThe questions we get asked.
What exactly does Calyraen provide?
Computing, engineering time and the cost of publishing. Our cluster runs continuously for research workloads, given rather than rented.
Who gets the credit for the science?
The researchers do. The questions, the method and the conclusions are theirs. We are the workshop, not the author.
Are the papers really free?
Yes. Every paper this work produces is free to read, in full, with no paywall and no expiry.
Why does a computer company work on medicine?
Because a lot of modern medicine is really a computing problem. We contribute the one thing we have plenty of: machines, and the people who run them.
Keep *reading*.
One index, kept current
See what the work has found.
The papers are free and the list grows as the research does. Start with the lead paper, or browse everything published so far.